Studimi ka treguar se bakteret që gjenden zakonisht në lëkurën tonë veprojnë si një "shtresë" e mundshme e mbrojtjes kundër kancerit
Ndodhja e kanceri i lëkurës has been steadily increasing over the past decades. Skin kancer is of two kinds – melanoma and non-melanoma. The most common type is the melanoma skin cancer which causes 2 and 3 million cases globally every year. The non-melanoma is not the most common type and affects 130,000 globally but is also serious because it can spread. One in every three kanceret i diagnostikuar në mbarë botën është një kancer i lëkurës. Lëkura jonë është organi më i madh i trupit dhe është gjithashtu më i rëndësishmi pasi mbulon të gjithë trupin dhe na mbron nga faktorët e jashtëm të dëmshëm si dielli, temperaturat jonormale, mikrobet, pluhuri etj. Lëkura është përgjegjëse për kontrollin e temperaturës së trupit tonë dhe largimin e djersës nga trupin tonë. E bën thelbësoren vitaminë D and marvellously, the skin provides us with a sense of touch. The main cause of skin kancer is overexposure to harmful rays of the sun. As the ozone layer in our atmosphere is gradually depleting the protective layer is going away leading to more UV (ultra-violet) radiation of the sun to reach the earth’s surface. Melanoma kancer, which starts in pigment-producing skin cells, is caused by abnormal changes in the skin when kanceroz cells start growing and the main factor is somehow connected with an individual’s exposure to the sun and their history of sunburn. Non-melanoma skin kancer starts in the cells of the lëkurë and grows out to destroy nearby tissue. This type of kancer generally does not spread to other parts of the body (metastasize) but melanoma cancer does.
Një studim i publikuar në Përparimet Shkenca përshkruan një rol të ri potencial të bakteret on our skin in protecting us against kancer. Researchers at UC San Diego School of Medicine, USA have identified a strain of the bakteret Staphylococcus epidermidis which is very commonly found on i shëndetshëm human skin. This unique strain of skin bakteret is seen to inhibit growth (kill) of several types of kanceret by producing a chemical compound – 6-N-hydroxyaminopurine (6-HAP) in mice. It was clear that only the mice which had this bakteriale strain on their skin and thus made 6-HAP did not have lëkurë tumours after they were exposed to kancer causing UV rays. The chemical molecule 6-HAP basically impairs the synthesis (creation) of DNA thereby preventing the spread of tumour cells and also suppressing the development of new skin tumours. The mice were injected with 6-HAP every 48 hours over a period of two weeks. The strain is non-toxic and does not affect normal healthy cells while reducing the already present tumours by almost 50 percent. The authors state that the bakteriale strain is adding “another layer” of protection to our skin against kancer.
This study clearly shows that our “skin microbiome” is an important aspect of the protection which skin offers. Some skin bakteret are already known for producing antimicrobial peptides which protect our skin from invasions by pathogenic bakteret. Further studies are required to understand the workings of 6-HAP and whether ideally it could be used as a preventative measure against kancer.
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Burimi (s)
Nakatsuji T etj. 2018. Një lloj komenzal i Staphylococcus epidermidis mbron nga neoplazia e lëkurës. Përparimet Shkenca. 4 (2). https://doi.org/10.1126/sciadv.aao4502
